Meet Tretinoin: The Only Medication Approved By The FDA To Treat Wrinkles (2023)

Meet Tretinoin: The Only Medication Approved By The FDA To Treat Wrinkles by Sarah Healy Meet Tretinoin: The Only Medication Approved By The FDA To Treat WrinklesFrustrated with your wrinkles? Thought so. In that case, a prescription-only topical tretinoin cream may be the answer you're looking for.Tretinoin: the only anti-aging medication approved by the FDATretinoin is an active ingredient that can help turnover our skin cells and boost collagen production so we can all have that smoother, tighter, more youthful look. In fact, it's so effective that it's only available as prescription from a visit with a dermatologist.. until now.Face-Rx: A do-it-all treatment that gives you easy access to tretinoinMusely created Face-Rx to streamline the process of getting a tretinoin prescription. The full treatment comes with these products that work together to combat any side effects you might experience using tretinoin alone:• a tretinoin-infused Night Cream• a skin-protecting moisturizer with SPF Day Cream• a gentle Cleanser that leaves sensitive and reactive skin purified, calm, and smooth• an eNurse app feature to guide you through your Face-Rx journeyNo doctors visits, no insurance, no problem.Face-Rx users can connect with a dermatologist, complete a digital assessment about their skin history, and receive a prescription. The entire process is online so you can start anytime, anywhere and we'll send the prescription right to your door. The Night Cream's key ingredients:• Tretinoin - tightens, tones, smoothes, & diminishes wrinkles• Hyaluronic acid - hydrates, boosts collagen & plumps• Niacinamide - brightens dark spots & fights dullnesseNurse: Your digital guide to your new skinOnce you begin your Face-Rx journey the eNurse feature allows you to easily track your results, communicate with dermatologists, and learn more about how the Face-Rx system is transforming your skin.


Is tretinoin FDA approved for wrinkles? ›

In 1995, topical tretinoin was approved by the FDA for the palliation of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial photodamage. How Tretinoin Treats Wrinkles and Signs of Aging? As we get older, our bodies begin to produce new skin cells at a slower speed.

What is better than tretinoin for wrinkles? ›

Tazarotene (Tazorac, Avage) is another type of retinoid that also comes in a cream or a gel, but is usually more expensive than tretinoin. In studies, it is as effective as tretinoin for photoaging and wrinkles but can cause more skin irritation.

Does tretinoin actually reduce wrinkles? ›

Tretinoin has been proven to prevent, reduce, and treat wrinkles. It also helps to treat and prevent age spots. By stimulating collagen production in the skin, it strengthens the skin at a structural level, resulting in a more youthful appearance.

Is retinol or tretinoin better for wrinkles? ›

In addition, several over-the-counter products containing retinoids, such as retinol, are available. Because they're not as strong (and thus less irritating), they are not as effective in reducing wrinkles as tretinoin; but they do improve the appearance of photo-aged skin.

Will A dermatologist prescribe tretinoin for wrinkles? ›

The only way to get this beloved medication, however, is through a dermatologist or doctor. Tretinoin is prescription-only.

How long should I use tretinoin for wrinkles? ›

On the whole, you should expect to see results from tretinoin after approximately three months of daily use, with more obvious and lasting results typically occurring from about six months to one year. It's important to remember that tretinoin is designed as a long-term treatment, not as a quick fix for wrinkles.

Is there anything better than tretinoin? ›

Tazarotene 0.1% cream was also found to produce results more quickly than tretinoin 0.05% cream in another study conducted in 173 patients with photodamaged facial skin. Tazarotene was found to better than tretinoin when: An overall integrated assessment of photodamage was made at week 16 of the study.

What works better than tretinoin? ›

Adapalene and tretinoin are both effective options for treating acne. Some studies have shown that adapalene causes less irritation than tretinoin but that tretinoin might be more effective. But the results are mixed. Other studies have found the two medications are equally effective at improving acne.

What cream is stronger than tretinoin? ›

Conclusions: Tazarotene 0.1% cream can offer superior efficacy over tretinoin 0.05% emollient cream in the treatment of facial photodamage, particularly with respect to the speed of improvement.

Can tretinoin reverse sagging skin? ›

Tretinoin is STILL the gold standard in anti-aging skin care products. It won't help with sagging due to loss of fat and bone over the years though.

Can I use tretinoin for years? ›

Usually a minimum of two to six months are needed to see noticeable results. Tretinoin is also safe to use over the long term, with some studies examining the effects of tretinoin for as long as four years.

Can I use tretinoin forever? ›

In Conclusion. Tretinoin is commonly used as a long-term treatment, whether for acne or anti-aging. Many studies show that tretinoin is most effective when used over a long period of time, especially for wrinkling and photoaging.

What retinol is stronger than tretinoin? ›

Tazarotene. The strongest of topical retinoids is tazarotene (also known as Tazorac), a retinoid that binds to both the beta and gamma retinoic acid receptors in the skin. It's used to address concerns such as acne, psoriasis, and photo damage of the skin.

Which is better for wrinkles retinol or vitamin C? ›

So, should I use vitamin C or retinol for wrinkles? Well, when it comes right down to it, the choice is really in what you're looking to do for your skin. While vitamin C is incredible for the skin because of its ability to help brighten and improve hyperpigmentation, the best active ingredient for wrinkles is retinol.

Do dermatologists recommend tretinoin? ›

Tretinoin (aka Retin-A) is an FDA-approved ingredient used to treat acne and anti-aging skin concerns. ¹ It's a potent vitamin A derivative, or retinoid. Dermatologists consider it the gold standard for treating breakouts and photoaging.

What prescription cream is best for wrinkles? ›

Tretinoin is considered to be the most widely used prescription retinoid treatment for wrinkles. It comes in the form of a gel. During use, you must wear sunscreen daily to protect your skin from sunburn and photoaging.

Do I just ask my dermatologist for tretinoin? ›

You can't purchase tretinoin over the counter - it's one of a few prescription retinoids on the market and getting your hands on some requires a visit with a board-certified dermatologist or other healthcare provider. Over-the-counter products tend to contain milder ingredients that have a lesser impact on your skin.

Should you put tretinoin under your eyes? ›

Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once. Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers.

What not to use with tretinoin? ›

Unless your doctor tells you otherwise, it is especially important to avoid using the following skin products on the same area as tretinoin: Any other topical acne product or skin product containing a peeling agent (eg, benzoyl peroxide, resorcinol, salicylic acid, or sulfur).

What happens when you stop tretinoin? ›

Your skin may become irritated.

During the first month or two, you may notice an increase in redness and acne. That's normal! Tretinoin speeds up cell death and renewal, and your skin needs time to adjust. These breakouts are temporary.

What is the strongest prescription tretinoin? ›

Tretinoin strengths

The strongest tretinoin available is 0.1%—that's 10 times stronger than the lowest percentage.

Why is everyone using tretinoin? ›

The Pros and Cons of Tretinoin

It increases cell turnover at your skin and prevents the clogging of pores that can lead to acne, blackheads, and other skin problems.

Can tretinoin make wrinkles worse? ›

He suggests using a product with a sun protection factor (SPF) of at least 29. “Someone using tretinoin (the generic name for Retin-A) would be crazy to go out in the sun without protection,” Voorhees says. “You could end up with more wrinkles than you would have had without Retin-A.”

What is A natural alternative to tretinoin? ›

“Rosehip seed oil is a great retinol alternative,” says Jaliman. “It's high in beta-carotene, vitamin C, and vitamin E.”

What is the success rate of tretinoin? ›

A more recent study published in 2013 found that more than 50 percent of people experienced improvements in acne from tretinoin, even when it was applied for only 30 minutes per day.

What is the strongest retinol you can buy over the counter? ›

RoC Retinol Correxion Deep Wrinkle Night Cream

Houshmand recommends RoC's Deep Wrinkle Night Cream, which is one of the highest-strength retinol you can get over the counter, meaning you may see its resurfacing effects sooner than with other products.

Can tretinoin get rid of jowls? ›

After 6-9 months of regular Tretinoin use, you may notice firmer, less saggy skin around the eyes and jawline and fewer wrinkles.

Does tretinoin tighten neck skin? ›

For fine wrinkling of the neck the use of 'wrinkle creams' can help firm and smooth the skin texture. Retinoids such as prescription tretinoin (Retin A) or a really good retinol such as my Retinol Intensive Anti-Wrinkle Night Cream.

Can tretinoin help turkey neck? ›

For an especially crepey neck, your doctor may recommend: Prescription retinoids – Topicals like tretinoin or adapalene can trigger skin cell turnover, encourage production of collagen and elastin, and thicken skin below the outermost layer.

What happens if you use tretinoin everyday? ›

Tretinoin can cause serious side effects, including intense irritation, redness, burning sensation, itching, dryness, and skin flaking.

Can topical tretinoin cause liver damage? ›

Retinoids (Accutane and Tegison) are used clinically for the treatment of a variety of skin diseases. Since retinoids are analogs of vitamin A, their potential to produce liver disease is reviewed. Animal and human studies of liver function tests suggest some abnormalities in the liver in about 25% of patients treated.

Is retinol good for skin over 60? ›

Because retinoids help your skin make more collagen, they soften wrinkles and fine lines. They also stimulate new blood vessels, which can give your skin a rosy color. Retinoids also help fade age spots and smooth rough patches. Tretinoin (Retin-A) is a popular prescription choice for aging skin.

Is tretinoin harmful long term? ›

A report in the American Journal of Clinical Dermatology concluded that retinoids are “suitable as long-term medications, with no risk of inducing bacterial resistance.” Another study tested the safety of tretinoin cream over 52 weeks and found no problems.

Should I wash tretinoin off in the morning? ›

Yes, tretinoin should be applied at night and washed off in the morning.

Can I leave tretinoin on overnight? ›

Usually tretinoin is applied at night so that it does not cause a problem with any other topical products that you might use during the day. Check with your doctor before using topical medicines with tretinoin. During the first 6 months of use, avoid overexposing the treated areas to sunlight, wind, or cold weather.

Is there a cream for deep wrinkles? ›

RoC Retinol Correxion Deep Wrinkle Night Cream visibly reduces the look of lines and deep wrinkles on your face while you sleep. This anti aging cream, containing pure RoC Retinol, leaves skin feeling smooth and younger looking.

What do dermatologists recommend for wrinkles on the face? ›

If you're looking for more-dramatic results, a dermatologist can recommend medical treatments for wrinkles, including prescription creams, botulinum toxin (Botox) injections or skin-resurfacing techniques.

Which is better for wrinkles retinol or hyaluronic acid? ›

Hyaluronic acid is best if they're looking to moisturize dry skin, while retinol works better by encouraging better skin by boosting collagen production. They have several benefits that can work in tandem for better results, though patients need to be careful with the exact formulations they use.

Does topical tretinoin cause weight gain? ›

Summary. Commonly reported side effects of tretinoin include: pleural effusion, dyspnea, edema, fever, hypotension, leukocytosis, weight gain, headache, hypercholesterolemia, hypertriglyceridemia, increased liver enzymes, nausea, visual disturbance, and vomiting.

How much is a tube of tretinoin? ›

The cost for tretinoin topical topical cream 0.05% is around $35 for a supply of 20 grams, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the discount card which is accepted at most U.S. pharmacies.

Why shouldn t you mix vitamin C and retinol? ›

Oils create a skin barrier, blocking the absorption of water-based products. Adding vitamin C (water-soluble) to retinol (oil-soluble) results in the non-absorption of vitamin C, thus no skin benefits. So, you see how mixing the two is a waste of skincare products, money, and time.

Can I use tretinoin and vitamin C together? ›

According to Dr. Sheila Krishna, it's totally fine to use vitamin C with over-the-counter retinol products or dermatologist-grade retinoids—which, BTW, is the broader term for vitamin A derivatives, including retinol, tretinoin, and adapalene, just to name a few.

What is FDA approved for wrinkles? ›

The FDA also has approved botulinum toxin products such as Botox, Dysport, Xeomin and Jeuveau to treat facial wrinkles. These products are not dermal fillers. They are injectable drugs that work by keeping muscles from tightening, so the wrinkles don't show as much.

Does tretinoin require prior authorization? ›

Prior Authorization is recommended for prescription benefit coverage of single-entity and combination topical tretinoin products.

What is the newest treatment for wrinkles? ›

The U.S. Food and Drug Administration (FDA) has approved Daxxify, a new injected medicine for smoothing facial wrinkles in adults, which dermatologists see as the first major competitor to Botox to emerge in decades.

What product actually gets rid of wrinkles? ›

Retinoids. This term is used for vitamin A compounds, such as retinol and retinoic acid. These ingredients have long been used topically to help repair sun-damaged skin and reduce fine lines and wrinkles.

Why you should stop using tretinoin? ›

Most people stop taking tretinoin when their skin clears up or if it isn't working after trying it for a while. A dermatologist is the best person to ask about when to start or stop taking tretinoin.

How to get insurance to pay for tretinoin? ›

You'll only get a tretinoin prescription covered by insurance if it's being prescribed by your dermatologist (or other healthcare provider) for acne treatment. Nearly all Medicare prescription drug plans cover Retin-A prescriptions to treat acne, as do most private insurance plans.

What are the cons of using tretinoin? ›

More common
  • Burning, itching, stinging, scaling, or redness of the skin.
  • chapping or slight peeling of the skin (mild)
  • darkening of the skin.
  • lightening of normal skin color.
  • lightening of treated areas of dark skin.
  • redness of skin (mild)
  • unusual dryness of skin (mild)
  • unusually warm skin (mild)
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